|  |  |  | | | | | Scientific American | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | MINNEAPOLIS--It’s a great irony of paleoanthropology that for all the insights scientists have been able to glean from the fossil record about our early ancestors, the australopithecines (Lucy and her kin), they have precious little to document the origin of our own genus, Homo. They know that Homo descended from one of those australopithecine species and that over the course of that transition our ancestors evolved from chimp-size creatures with short legs and small brains into tall humans with long legs and large brains, among other hallmark traits. But the details of this evolutionary transformation--when the distinctive Homo characteristics arose and why--have remained elusive, because fossils of early Homo are rare and the ones that have turned up are generally too fragmentary to yield much information. To that end, last spring Lee Berger of the University of the Witwatersrand in Johannesburg, South Africa, and his colleagues announced their discovery of two partial human skeletons ( pictured above ) from that mysterious period that might well revolutionize researcher’s understanding of how our genus got its start. The specimens, which date to around 1.95 million years ago, were said to exhibit a mosaic of traits linking them to both Australopithecus and Homo, leading the team to propose that they represent a previously unknown species of human-- Australopithecus sediba --that could be the direct ancestor of Homo. The interpretation was controversial . Some critics argued that the fossils do belong in Australopithecus, but have no special relationship to Homo; others contended that they represent a dead-end branch of Homo, rather than ancestor of later species, including H. sapiens. [More]  | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | How funnels form, what drives tornado activity, and what scientists are doing to better understand them--our collection of articles, video and podcasts explain the basics [More]  | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | The traditional view of proteins is that, right after being synthesized, they must fold into a unique shape to function properly. Unstructured proteins, according to biological orthodoxy, are pathological. Recent studies, however, are showing otherwise, as A. Keith Dunker and Richard W. Kriwacki explain in the April issue of Scientific American . In fact, remaining unfolded is crucial for proteins such as p27. In this computer simulation, p27 is seen continuously morphing under the action of brownian motion (collision with water molecules, not shown) and of its own thermal vibrations. [More]  | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | Proteins are the stuff of life. They are the eyes, arms and legs of living cells. Even DNA, the most iconic of all molecules in biology, is important first and foremost because it contains the genes that specify the makeup of proteins. And the cells in our body differ from one another--serving as neurons, white blood cells, smell sensors, and so on--largely because they activate different sets of genes and thus produce different mixtures of proteins. Given these molecules’ importance, one would think biologists would have long figured out the basic picture of what they look like and how they work. Yet for decades scientists embraced a picture that was incomplete. They understood, quite properly, that proteins consist of amino acids linked together like beads on a string. But they were convinced that for a protein to function correctly, its amino acid chain first had to fold into a precise, rigid configuration. Now, however, it is becoming clear that a host of proteins carry out their biological tasks without ever completely folding; others fold only as needed. In fact, perhaps as many as one third of all human proteins are “intrinsically disordered,” having at least some unfolded, or disordered, parts. [More]  | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | | | | | | | |  |  |  | | | | | | | | | | |  |  |  |  |  | |
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